abstract |
The present invention relates to a cocoon-derived papain enzyme decomposition product having excellent skin inflammation improving activity and a use thereof, and in particular, the present invention relates to a method for preparing a papain enzyme digestion product of a cocoon having an activity to inhibit or improve skin inflammation, the method It relates to a cosmetic composition for improving skin inflammation, comprising a papain enzyme decomposition product for the ultrasonic extract of the cocoon prepared as an active ingredient, a health functional food, and a pharmaceutical composition for preventing or treating skin inflammation. The papain enzyme decomposition product of the cocoon according to the present invention has excellent inhibitory activity of COX-2 and PGE2, which are factors causing skin inflammation, and at the same time can inhibit phosphorylation of extracellular-signal-regulated kinase (ERK), It can be usefully used in the manufacture of cosmetics, medicines and health functional foods for the prevention, improvement or treatment of skin inflammation. |