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filingDate 2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-102111025-B1
titleOfInvention Cosmetic Composition for Anti-aging or Anti-wrinkles Comprising Neural Stem Cell Conditioned Medium and Method for Preparing the Same
abstract The present invention is a neuronal stem cell culture solution excellent in skin wrinkle improvement or skin elasticity enhancement that contains a high concentration of TIMP-1 and TIMP-2 capable of inhibiting the expression and activity of MMPs (matrix metalloproteinases) involved in collagen decomposition in the dermis. It relates to a manufacturing method. The neural stem cell culture medium containing high concentrations of TIMP-1, TIMP-2 and low concentrations of various MMPs according to the present invention restores the synthesis of collagen and elastin by inhibiting the expression and activity of MMPs that inhibit collagen production, It is useful as a composition for improving skin wrinkles or enhancing skin elasticity.
priorityDate 2018-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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