http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102111009-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-216 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-216 |
| filingDate | 2018-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102111009-B1 |
| titleOfInvention | Anticancer prodrug for creating with two quinone metide, and method for preparing the same |
| abstract | The present invention relates to an anti-cancer precursor represented by Formula 1 below. The anti-cancer precursor of the present invention can rapidly alkylate the antioxidant GSH by releasing two quinonemethides by esterase, thereby inhibiting the antioxidant system and significantly increasing oxidative stress. That is, the anti-cancer precursor of the present invention induces the death of cancer cells through an increase in oxidative stress due to GSH deficiency. In addition, the anticancer precursor of the present invention induces the loss of the mitochondrial membrane, inhibits the expression of apoptosis-related protein Bcl-2, and induces cleavage of caspase-3 and PARP-1. In addition, the anti-cancer precursor of the present invention significantly inhibits the growth of tumors and does not cause chronic damage even when administered for a long period of time, and thus may be useful for the prevention or treatment of cancer. [Formula 1] In Chemical Formula 1, R is an alkyl group, a phenyl group, a naphthyl group, or an anthracenyl group selected from the group consisting of methyl, ethyl, propyl, butyl, and t-butyl, respectively. |
| priorityDate | 2018-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 121.