abstract |
The present invention includes modified nucleotides, such as LNA, ENA, polyalkylene oxide-, 2'-fluoro, 2'-O-methoxy and / or 2'-O-methyl modified nucleotides, TGF -Beta2 nucleic acid sequence is directed to an oligonucleotide consisting of 10 to 18 nucleotides of a selected region. The present invention also relates to pharmaceutical compositions comprising such oligonucleotides, wherein the composition or the oligonucleotides are malignant and / or benign tumors, immunological diseases, fibrosis, or ophthalmic diseases such as dry eye, It is used for the prevention and / or treatment of glaucoma or posterior capsule turbidity (PCO). |