| abstract |
Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification includes deletion of an endogenous low affinity FcγR locus, and the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice, including mice expressing a low affinity human FcγR gene from an endogenous FcγR locus, are described, which mice include a functional FcRγ-chain. Genetically modified mice expressing up to five low affinity human FcγR genes on accessory cells of the host immune system are provided. |