| abstract |
The present invention is a metallo-beta-lactamase inhibitor compound of formula I: And pharmaceutically acceptable salts thereof, wherein Z, R A , X 1 , X 2 and R 1 are as defined herein. The invention also includes the metallo-beta-lactamase inhibitor compounds of the invention or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable carriers, optionally in combination with beta lactam antibiotics and / or beta-lactamase inhibitors. The invention further treats a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally one or more beta-lactamase inhibitor compounds. It is about how. The compounds of the invention are useful in the methods described herein to overcome antibiotic resistance. |