http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102083408-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2017-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102083408-B1 |
| titleOfInvention | Method for stem cell based toxicity screening |
| abstract | The present invention relates to a method for screening a toxic substance based on stem cells. Specifically, a target gene called SERPINB2 is identified through DNA and RNA analysis after treating dioxin, which is well known as a toxic and carcinogen, to human umbilical cord blood-derived stem cells. The SERPINB2 gene was also found in the stem cells derived from breast cancer, colon cancer, and liver cancer that play an important role in the metastasis and recurrence of stem cells isolated from the fat of dioxin-treated mice and cancer. After confirming the response by dioxin, the SERPINB2 gene also responded to various toxic and carcinogens in addition to dioxin in human umbilical cord blood-derived stem cells and various cancer stem cells, and inserted the SERPINB2 gene reporter vector into human umbilical cord blood-derived stem cells. After treatment with dioxin, fluorescence is expressed. By the final confirmation that, SERPINB2 gene may be useful in a variety of poisonous and quickly whether and how much the treatment of toxic carcinogens, accurate and effective stem cell-based screening methods that can be toxic to predict. |
| priorityDate | 2017-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.