| abstract |
The present invention provides methods for the preparation and use of peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that inhibit FAAH activity and increase anandamide levels outside the central nervous system (CNS). The present invention also provides methods of inhibiting FAAH as well as, but not limited to, methods of treating conditions such as pain, inflammation, immune diseases, dermatitis, mucositis, hypersensitivity of peripheral sensory neurons, neurodermatitis and overactive bladder. Accordingly, the present invention also provides compounds, methods and pharmaceutical compositions for treating conditions in which selective inhibition of peripheral FAAH (as opposed to CNS FAAH) is useful. |