http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102078439-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D221-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-84 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-84 |
| filingDate | 2017-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102078439-B1 |
| titleOfInvention | Hydrazide-linked naphthalimide derivative and use for imaging a copper pool thereof |
| abstract | FIELD OF THE INVENTION The present invention relates to hydrazide-linked naphthalimide derivatives and their copper pool imaging applications, which are ratiometric fluorescent probes for detecting copper ions in living cells. A hydrazide-linked naphthalimide (Formula 1) was developed. The inventors have confirmed through ratiometric fluorescence changes that compound 1 and compound 2 are hydrolyzed to compound 3 and compound 4 by Cu + and Cu 2+ ions, respectively, under physiological conditions, and compound 1 is biocompatible. (biocompatible), live HeLa cells within the endoplasmic reticulum; was mainly located in the (endoplasmic reticulum ER), copper ion evaluator has confirmed that indicate readily the ratiometric fluorescence varies with the catalytic hydrolysis of the (Cu + and Cu 2 +), the The invention can be widely used in chemical, biological and environmental engineering processes. |
| priorityDate | 2017-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.