| abstract |
The present invention relates to a dopamine neuron specific expression control system, which is a technique for controlling expression of dopamine cell-specific target genes using a vector including THP and tTA and a vector including TetO and a target gene, and according to the present invention, AAV-THP -tTA vector can induce the expression of disease genes acutely dopamine cell-specific, inducing dopamine cell-specific disease lesions, this cell specificity is useful for drug screening or molecular mechanism study of the lesion, dopamine The expression of target genes can be specifically controlled by TetO in a cell specific target protein expression control system, which can be utilized to study the function, pathological role and molecular mechanisms of various genes in dopamine specific diseases. Can be. |