http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102050043-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5ad8562c578b061df7a2c3aee9d0e24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0033 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
| filingDate | 2018-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ea1b7ac4a62e37b6435eda5b234c2db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9cc44736a114651c466dd435a63f9cff |
| publicationDate | 2019-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102050043-B1 |
| titleOfInvention | An siRNA delivery system comprising mesoporous silica particle and metal ions, to which siRNAs enable to bind, on the surface and within the pores of the particle, preparation method thereof and use thereof |
| abstract | The present invention includes mesoporous silica nanoparticles (MSNS) having fine pores with an average diameter of 5 nm or less and expanded pores of 10 to 50 nm, and siRNA bound to the outer surface and the pore inner surface of the particles. As siRNA carriers, the pore inner surface and the outer surface of the particles, including the first metal ions and the second metal ions, siRNA is coupled to it through, siRNA transporter. In addition, the present invention relates to a method for producing the siRNA carrier, and to a pharmaceutical composition for treating cancer comprising the siRNA carrier. The siRNA transporter according to the present invention, using a bivalent metal cation such as calcium ions that are biologically safe, can load siRNA on MSN without functionalization with amines, which is conventional and cytotoxic and can cause side effects. have. Therefore, the siRNA transporter of the present invention exhibits excellent biocompatibility, can stably deliver the siRNA into the cell, and can carry a synergistic effect by simultaneously delivering genes and drugs by carrying additional drugs in the pores, thereby treating cancer. It can be used as a pharmaceutical composition for. In addition, the siRNA transporter of the present invention can be prepared in a simple, one-pot by a simple method of mixing the salt of siRNA, the first metal ion-containing mesoporous silica nanoparticles and the second metal ion, siRNA transporter of the present invention Since it can be extended to a wide range of silica particles having a variety of properties in terms of the size of the pores and particles, and the surface composition and the like, it can provide a novel type of siRNA carrier and manufacturing method. |
| priorityDate | 2018-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.