| abstract |
The present invention relates to a nucleic acid molecule capable of binding to human C5a, wherein the nucleic acid molecule comprises a central stretch of nucleotides, the central stretch of nucleotides 5 'AUGn 1 GGUGKUn 2 n 3 RGGGHUGUKGGGn 4 Gn 5 CGACGCA 3' [SEQ ID NO: 61], Where n 1 is U or dU, n 2 is G or dG, n 3 is A or dA, n 4 is U or dU, n 5 is U or dU, alc G, A, U, C, H, K and R are ribonucleotides, and dU, dG and dA are 2'-deoxyribonucleotides. |