| abstract |
Provided are hollow silica nanoparticles containing gold nanodots for chemical and photothermal treatment, dopamine and hyaluronic acid combined, gold nanodots containing hollow silica nanoparticles loaded with drugs, in particular targeted therapeutic drugs, and methods for their preparation. . This manufacturing method can proceed in situ in the morphology control of the hollow silica nanoparticles and the formation of gold nano-dots in one step, the manufacturing process is easy, there is an advantage that does not use a surfactant. In addition, the combination of dopamine and hyaluronic acid can improve the photothermal effect, lower cytotoxicity and increase biocompatibility, prevent inadvertent drug release, impart tumor targeting and concomitant treatment The effect can be enhanced. |