| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f992abfde71d27c482537ab9ce0bca81 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-331
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2236-51 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-535
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-535
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48 |
| filingDate |
2018-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd3854998563db56987830ec23ef129f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6f726e4e36dc946812f17a464f4999e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63e8a35f8832389e7a175b3efd565e39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_384ee52b476f4422c40dd744fa36f660
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be67b2150bb8ca605d4944e5bb62bbf2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d814d3ff610df750fd7a3f39ffbf97a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36fe6739f22b9a194d411a72f00a7d64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9684a92de5f5b1e9a08ccbe5b9080817
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4730c562e32a8876af79d2d1e189b5d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17f3297d9b9a50ade56457060476290e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e57aa77f485507a2f8d9e8254c16f383
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a213102c6cfcb73a9ee1342e82c2f5fc |
| publicationDate |
2019-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-102027699-B1 |
| titleOfInvention |
Pharmaceutical composition comprising luteolin-7-o-diglucuronide, apigenin-7-o-diglucuronid isolated from perilla frutescens var. acuta leaf extract for improving ocular fatigue |
| abstract |
The present invention relates to a health functional food showing the eye fatigue prevention and improvement of the luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide compounds contained in the extract of Chazuki. It was confirmed that the active ingredient contained equally luteolin-7-O-diglucuronide and apigenin-7-O-diglucuronide compounds. Cyclomuscular cells (rCSMCs) isolated from rat eyes increased NO and cGMP contents related to eye relaxation. [Ca 2 + ] i Ion content was reduced. Animal testing also increased cGMP content. These compounds can be used in a dietary supplement composition useful for preventing and improving eye fatigue by increasing the cGMP content in ciliary muscle cells isolated from rat eyes. |
| priorityDate |
2018-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |