http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102022763-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 |
| filingDate | 2017-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102022763-B1 |
| titleOfInvention | pH sensitive polymer complex for photochemo combination therapy and preparing method thereof |
| abstract | The present invention relates to a pH-reactive polymer complex and a method for preparing the same for photochemical combination therapy, and a polymer in micelle form consisting of polyethylene glycol, cationic polyamino acid and polylactic acid and doxorubicin encapsulated in the polymer. And a pH-sensitive reactive polyionic complex (PIC) prepared by incorporating a pH sensitive reactor and a photosensitizer (chlorin e6) to the side branches of the cationic polyamino acid in the polymer, respectively, to form a nano-sized aggregate, In a cancer cell environment exhibiting weak acidity, pH-dependent photosensitizers can be dissociated from micelles to improve singlet oxygen production and antiproliferative activity. Therefore, the pH reactive diionic complex having the above effect can be utilized as a nano drug platform for photochemical combination therapy to maximize the therapeutic efficacy. |
| priorityDate | 2017-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.