| abstract |
The present invention is directed to a compound that inhibits the activity of an anti-apoptotic Bcl-xL protein, a composition comprising the compound, and a method for treating a disease, such as cancer, in which an anti-apoptotic Bcl-xL protein is expressed during a disease. It is about. Formula I In Formula I, X is heteroaryl; Y 1 is phenylene or C 5-6 heteroarylene; L 1 is a linker; Y 2 is cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; Z 1 is C (O) OR 9 , C (O) NR 10 R 11 , C (O) R 11 , NR 10 C (O) R 11, and the like. |