http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102016421-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S514-912 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2250-21 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-744 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-105 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-744 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 |
| filingDate | 2016-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-102016421-B1 |
| titleOfInvention | Composition for preventing or treating macular degeneration comprising surface-modified gold nanoparticles by extract of Gardenia jasminoides |
| abstract | The present invention relates to a composition for preventing or treating macular degeneration containing gold nanoparticles surface-treated with the gardenia extract as an active ingredient, the gold nanoparticles surface-treated with the gardenia extract of the present invention is hydrogen peroxide (H 2 O 2 ) It does not show cytotoxicity in human retinal epithelial cells ARPE19 induced by cellular aging, and can increase antioxidant and anti-aging effects by reducing lysosomal content, free radical species and aging-related beta galactosidase by hydrogen peroxide. have. In addition, it is possible to restore G2 / M phase arrest by hydrogen peroxide in the cell cycle, reduce the protein expression of p53 and p21 increased by hydrogen peroxide, and increase the expression of SIRT3 protein, an anti-aging marker. Therefore, the composition of the present invention containing the gold nanoparticles surface-treated with the gardenia extract having the above effects as an active ingredient can be utilized as a pharmaceutical composition for preventing or treating macular degeneration, or a health food composition for preventing or improving macular degeneration. Can be. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023182606-A1 |
| priorityDate | 2016-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 239.