| abstract |
The present invention relates to a process for preparing aryl- and heteroaryl acetic acids and derivatives thereof by reacting an aryl or heteroaryl halide with a malonic acid diester in the presence of a palladium catalyst, at least one base and optionally a phase transfer catalyst. This process also makes it possible to prepare a large number of functionalized aryl- and heteroaryl acetic acids and their derivatives, more particularly the production of aryl acetic acid with steric hindered substituents. |