http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101987354-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2200-318 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23V2002-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 |
| filingDate | 2017-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101987354-B1 |
| titleOfInvention | Composition comprising peptide derived from thioredoxin-interacting protein or polynucleotide encoding the peptide for rejuvenation of stem cell |
| abstract | The present invention relates to a pharmaceutical composition for reverse-aging stem cells comprising a peptide derived from a thioredoxin-interacting protein (TXNIP) or a polynucleotide encoding the same, wherein the TXNIP- (HSC), increased engraftment of older HSCs, decreased sequence bias tendency, decreased LT-HSC (long-term HSC) ratio, p38, and ROS, and confirmed that the administration of the TXNIP-derived peptide promoted the leukocyte proliferation of the old mice to the level of the young mice in the acute leukopenia model, and that TXNIP Derived peptides restore the polarity of Cdc42 in old HSC, By confirming that that decreases the former, p16, p19, p21 and the expression of Wnt5a, increase the homing (homing) of HSC, TXNIP-derived peptides of the invention may be useful as a reverse nohwayong composition of hematopoietic stem cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102547965-B1 |
| priorityDate | 2016-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 383.