| abstract |
(A) an influenza hemagglutinin HA1 domain comprising an HA1 N-terminal stem segment covalently linked to the HA1 C-terminal stem segment by a connecting sequence of 0 to 50 amino acid residues, and (b) An influenza hemagglutinin stem domain polypeptide comprising a hemagglutinin HA2 domain, wherein the influenza hemagglutinin stem domain polypeptide in which one or more amino acids in the HA2 domain are mutated. Also provided are compositions comprising nucleic acids, polypeptides and / or nucleic acid molecules encoding polypeptides and, in particular, methods for their use in the detection, prevention and / or treatment of influenza. |