http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101974202-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_65bf5020a8c2ba50db1b40672e0a8fa1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 |
| filingDate | 2018-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c483cdc4821e8ca94748d7976b411d5c |
| publicationDate | 2019-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101974202-B1 |
| titleOfInvention | Composition for preventing or treating diabetes and method for screening antidiabetic agents using CD9 |
| abstract | The present invention relates to a composition for preventing or treating diabetes using CD9 and a method for screening a therapeutic agent for diabetes. More particularly, the present invention relates to a composition for inhibiting the expression or activity of CD9 protein or an insulin secretory cell comprising CD9 gene- (A) contacting the test substance with a cell expressing the CD9 gene; (b) measuring the level of CD9 gene expression in a control cell not in contact with the test substance; And (c) screening a test substance that reduces the level of CD9 gene expression as compared to a control cell, as a candidate for a diabetic therapeutic agent. The present invention can be usefully used to develop a therapeutic agent for diabetes, which has completely novel mechanism of inhibiting the expression or activity of CD9 protein through the increase of insulin secretion amount due to CD9 inhibition. In addition, insulin secretory cells in which the CD9 gene is knocked out are administered or transplanted into an individual, resulting in an increase in insulin secretion, a decrease in the blood glucose level in the subject, and an excellent ability to regulate blood glucose level, thus being useful as a therapeutic agent for diabetes . |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020017788-A1 |
| priorityDate | 2018-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1115.