| abstract |
An antibody or an antigen-binding fragment thereof that specifically binds to EGFRvIII (Epidermal Growth Factor Receptor Variant III), a nucleic acid encoding the antibody, an expression vector comprising the nucleic acid, a cell transformed with the expression vector, A method for producing an antigen-binding fragment, a viral vector comprising a nucleic acid encoding the antibody, a pharmaceutical composition for treating cancer or tumor comprising the antibody or an antigen-binding fragment thereof, a composition for detecting cancer and a kit, A chimeric antigen receptor comprising a binding fragment, a genetically modified immune cell expressing said chimeric antigen receptor, and a pharmaceutical composition for treating cancer or tumor comprising said immune cell. An antibody or antigen-binding fragment thereof that specifically binds to EGFRvIII according to one aspect binds only specifically to EGFRvIII without cross-reacting with the EGFR wild type (EGFRwt), and thus is useful for the treatment or prevention of various diseases caused by the expression or overexpression of EGFRvIII It can be used for diagnosis. |