| abstract |
The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of brain tumors, in particular glioblastomas, and compositions containing such compounds. The present invention provides an effective treatment for brain tumors and can be used by oral administration of a compound of formula I as further described herein. Also disclosed is a genetic signature correlated with a successful therapy using the method: (I) In this formula, R 1 is alkylpyrazole or alkylcarboxamide, and R 2 is hydroxycycloalkyl. |