http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101927614-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L2203-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G73-1092 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08L79-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G73-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L79-08 |
| filingDate | 2017-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101927614-B1 |
| titleOfInvention | Preparing method of contrast agent with stable oxygen-nanobubble or ultrasound imaging |
| abstract | The present invention relates to a method for preparing a stable biocompatible oxygen-nano bubble contrast agent for ultrasound imaging, and more particularly, to a method for preparing a biocompatible oxygen- Poly (2-hydroxyethyl aspartamide) (hereinafter referred to as " PHEA "); Synthesizing an amphiphilic polyamino acid derivative represented by the following formula (1) by grafting the PHEA with a protoporphyrin compound contained in the center of iron; Mixing the synthesized amphiphilic polyamino acid derivative with a lipid to form a lipid thin film; And a step of injecting a solvent containing oxygen gas into the lipid thin film to prepare an oxygen-nano bubble in which oxygen gas is trapped, thereby producing an oxygen-nano bubble contrast agent composition for an ultrasonic wave. [Chemical Formula 1] In Formula 1, R 1 to R 10 may be the same or different, Hydrogen or an iron represented by the following formula (1-1) [Formula 1-1] N is an integer from 3 to 600; The method for preparing a stable biocompatible oxygen-nanobubble contrast agent for ultrasound imaging according to the present invention can synthesize an amphiphilic polyamino acid derivative by grafting a hydrophilic molecule-containing porphyrin compound to a hydrophilic polymer backbone, The amphipathic polyamino acid derivative can self-assemble with the lipid bilayer to stably capture the oxygen gas at the central portion, thereby making it possible to produce a biocompatible oxygen-nanobubble contrast agent. |
| priorityDate | 2017-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.