| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-727
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-999 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-067
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5067 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2016-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2018-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-101918817-B1 |
| titleOfInvention |
Method for differentiation of hepatocyte derived from human stem cells and Hepatocyte |
| abstract |
The hepatocyte differentiation induction method of the present invention can effectively acquire a larger number of hepatocytes than the prior art. Specifically, step A, in which human precociousment stem cells are treated with TrypLE TM select in three steps to purify only highly purified undifferentiated stem cells, Treating the purified undifferentiated stem cells with Activin A and CHIR99021 simultaneously to obtain endodermal cells; Treating the obtained endodermal cells with retinoic acid (RA) to obtain a hepatocyte; And D stage in which hepatic stem cells are induced by suspending the obtained hepatic stem cells on a differentiation plate, attaching them to a 96-well plate capable of evaluating toxicity, treating HGF (hepatocyte growth factor) and DEX (Dexamethasone) A stem cell-derived hepatocyte differentiation method comprising the steps of: |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20230071224-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20230102323-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20230103508-A |
| priorityDate |
2016-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |