| abstract |
The present invention relates to compounds of formula I and their pharmaceutically acceptable salts. The invention is also directed to a method of treating or preventing Down syndrome,? -Amyloid vasculopathy such as, but not limited to, brain amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as MCI ("mild cognitive impairment" Such as Alzheimer's disease, Alzheimer's disease, Alzheimer's disease or Alzheimer's disease, Alzheimer's disease or dementia (including dementia of mixed blood vessel and degenerative origin, senile dementia, senile dementia and Parkinson's disease) Related disorders, such as neurodegeneration, progressive supranuclear palsy, or cortical basal degeneration associated with neurodegenerative diseases such as Parkinson's disease. |