| abstract |
The present invention relates to a 5-arylfuran-2-carboxyamide derivative substituted by a cyclic amine group, a process for preparing the same, and a pharmaceutical composition for preventing or treating a disease associated with the activity of the urotensin-II receptor comprising the same as an active ingredient. The 5-arylfuran-2-carboxyamide derivative substituted by a cyclic amine group according to the present invention acts as an antagonist to the urotensin-II receptor and thus can be used for the treatment of congestive heart failure, cardiac ischemia, myocardial infarction, cardiac hypertrophy, II receptor activity-related diseases such as atherosclerosis, hypertension, asthma, renal failure, diabetes, vascular inflammation, neurodegenerative diseases, stroke, pain, depression, psychosis, cancer and the like. |