abstract |
A method for screening, identifying, or verifying the marker CACNA2D1 of tumor-initiating cells is disclosed. The method comprises immunizing an animal with HEP-12 cells derived from recurrent tumors and rich in progenitor cells. Also disclosed are monoclonal antibodies or antigen-binding fragments thereof that specifically recognize CACNA2D1, and their use for treating or preventing CACNA2D1 related diseases or disorders, or tumors. |