http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101880790-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2015-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101880790-B1 |
| titleOfInvention | Nanoparticles for genes drug delivery with siRNA for the long -term treatment of retinal disorders and method for preparing the same |
| abstract | The present invention relates to a self-assembled and condensed high molecular weight siRNA core particle and a particle for efficiently delivering a large amount of siRNA into the inside of the retina by coating the outside with a cationic polymer and hyaluronic acid, and a method for producing the same. Since the core of the present invention contains at least 1 x 10 6 small interfering RNA (siRNA) or antisense nucleic acids, it can deliver a larger amount of siRNA than the conventional one. By coating the outer shell with (-) charged hyaluronic acid, it is possible to prevent aggregation with the vitreous meshwork structural materials having (-) charge and reach the inner limiting membrane of the retina. In addition, hyaluronic acid binds to the CD44 receptor of Muller cells, allowing the structure of the retina to pass through the sub-retinal space through the transcytosis mechanism. Some of them inhibit the translation of target gene mRNA in Muller cells, and many of them bind to the CD44 receptor present in the retinal pigment epithelial (RPE) cell membrane and enter the cell to analyze the mRNA of the target gene in RPE translation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020231105-A1 |
| priorityDate | 2015-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.