| abstract |
Disclosed are a novel compound isolated from an Aruncus americanus extract, and an anti-inflammatory composition using the same. The novel compound inhibits production of NO, PGE_2, and inflammatory cytokines (TNF-α and IL-6) and suppresses production of iNOS and COX-2 in macrophages stimulated by lipopolysaccharide (LPS). In addition, the compound also inhibits activation of IκB, p38 (p38 MAPK), extracellular signal-regulated kinases 1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK). |