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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04
filingDate 2015-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2018-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-101855611-B1
titleOfInvention Process for the preparation of (r,s)-nicotine
abstract Reacting the nicotinate ester with N-vinyl-2-pyrrolidinone in the presence of a base and a solvent to form a first mixture, combining the first mixture with the acid to form a second mixture comprising an aqueous layer, Separating the aqueous layer from the mixture, combining the separated aqueous layer with the acid to form the third mixture, combining the third mixture with the base to form a fourth mixture comprising myosmin, and using myosmin as the reducing agent, (R, S) -nicotin, comprising the step of reducing the N, N-dihydroxyacetophenone to methyl, and methylating the nornicotine to obtain R, S-nicotine.
priorityDate 2014-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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