http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101850065-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff283c7d6797987f01db547f606e6b32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7970e52ae37d06074d5f8d1b8a857bf5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-902 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-046 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-723 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2016-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50647b1513d9d6dc4fe674be276b0a8d |
| publicationDate | 2018-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101850065-B1 |
| titleOfInvention | Information providing method for drug treatment decisions of hypothyroidism patients by TSHR mutations and DIO2 T92A single nucleotide polymorphism detection |
| abstract | The present invention provides a microarray, a kit and a kit for diagnosing hypothalamic hypothyroidism requiring simultaneous administration of L-T3 (liothyronine) in addition to monotherapy in which L-T4 (Levothyroxine) alone is administered in association with the treatment of hypothyroidism And a diagnostic method using the same. Specifically, C.274A> G of the DIO2 (type 2 iodothyronine deiodinase) gene (A on the DIO2 gene encoding the 274th base of the mRNA sequence encoding the DIO2 protein is changed into G) isozyme SNP and TSHR (Thyroid Stimulating Hormone Receptor) gene has a loss-of-function mutation in C.1349G > A (a change in A on the TSHR gene encoding the 1349th base in the mRNA sequence encoding the TSHR protein) , The expression and activation of DIO2 protein by thyroid stimulating hormone (TSH) was significantly inhibited. The SNP and TSHR mutations of the DIO2 gene were detected in the diagnosis of hypothyroidism patients requiring concurrent administration of L-T3 Can be usefully used. |
| priorityDate | 2016-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 310.