| abstract |
Disclosed herein are antibodies that bind to amyloid beta-derived diffusible ligands, also known as ADDLs. The antibody of the present invention is selective for ADDL, permeable to the brain, and useful in a method for detecting ADDL and diagnosing Alzheimer's disease. This antibody is also useful in methods for blocking the binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation, thus preventing and treating diseases associated with ADDLs. |