abstract |
The present invention relates to antisense oligonucleotides that modulate the expression and / or function of pyrroline-5-carboxylate reductase 1 (PYCR1), particularly the natural antisense of pyrroline-5-carboxylate reductase 1 (PYCR1) polynucleotide Lt; RTI ID = 0.0 > polynucleotides. ≪ / RTI > The present invention also relates to the identification of such antisense oligonucleotides and to the use thereof for the treatment of diseases and disorders associated with the expression of PYCR1. |