abstract |
It is an object of the present invention to provide a method of promoting antigen uptake into antigen-binding molecule-mediated cells, a method of promoting reduction of antigen concentration in plasma, a method of increasing the number of antigens that single antigen- , Methods of improving the pharmacokinetics of antigen-binding molecules, improved antigen-binding molecules for enhanced antigen uptake into cells, antigen-binding molecules capable of promoting a reduction in antigen concentration in plasma, Antigen-binding molecules with improved pharmacokinetics, pharmaceutical compositions comprising such antigen-binding molecules, and methods of making the foregoing. We have found that antigen uptake into cells is facilitated by antibodies having lower FcRn-binding activity at plasma pH and lower antigen-binding activity at the initial endosomal pH than at plasma pH; Such an antibody may increase the number of antigens to which a single antigen-binding molecule can bind; Reduction of plasma antigens can be facilitated by administration of such antibodies; It has been found that antibody pharmacokinetics can be improved by using such antibodies. |