| abstract |
The present invention relates to the provision of a medicament, in particular a compound which can be used as an agent for the treatment of irritable bowel syndrome (IBS). 1-on derivative or a pharmaceutically acceptable salt thereof, which has an amide group at the 4-position, has excellent bombesin 2 (BB2) receptor antagonism. In addition, it has been found that these tetrahydroisoquinolin-1-one derivatives exhibit excellent efficacy against throwaway anomalies. In view of the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a medicament for IB2 receptor-mediated diseases, particularly IBS. |