abstract |
The present invention relates to antibodies having therapeutic effect against cancer, autoimmune diseases or inflammatory diseases. That is, the present invention relates to an antibody that exhibits cytotoxic activity through apoptosis to a des-domain-containing receptor expressing cell. A subject of the present invention is to provide a medicament having a therapeutic effect on cancer. The new anti-DR5 antibody capable of inducing apoptosis in the cell has remarkable cytotoxic activity as compared with the existing anti-DR5 antibody. |