| abstract |
The present invention also relates to the use of 2-oxo-2,3-dihydro-indole of formula (I) as well as its pharmaceutically acceptable salts, racemic mixtures, or the corresponding enantiomers and / or optical isomers and / or stereoisomers thereof It is about: I In this formula, Ar is a heteroaryl group containing 1, 2 or 3 heteroatoms selected from N, O or S; R 1 is hydrogen, lower alkyl, halogen, amino, dimethylamino, cyano, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, CH (OH) CF 3, (CH 2) o - lower alkoxy, optionally a heterocycloalkyl is substituted by a cycloalkyl, or lower alkyl optionally substituted by CF 3; R 2 is hydrogen, lower alkyl, (CH 2) o - cycloalkyl, (CH 2) o -0- cycloalkyl, (CH 2) o - lower alkoxy, substituted by halogen (CH 2) o - lower alkoxy , (CH 2) optionally substituted by lower alkyl, o - heterocycloalkyl, (CH 2) o -S ( 0) 2 - cycloalkyl, lower alkyl, one or two optionally substituted by one or two hydroxy (CH 2 ) o -S (O) 2 -lower alkyl, lower alkyl substituted by halogen, or CH 2 CH (OH) CF 3 ; R < 3 > is halogen or lower alkyl; X is CH or N; X 1 is CH or N; n is 1 or 2; o is 0, 1, 2 or 3; m is 0, 1 or 2; The dotted line is a bond or not a bond. The compounds are useful for the treatment and / or prevention of schizophrenia, including both positive (psychotic) and negative symptoms of schizophrenia, drug abuse, alcohol and drug addiction, obsessive compulsive disorder, cognitive impairment, bipolar disorder, mood disorder, major depression, , Parkinson's disease, chronic pain, borderline personality disorder, sleep disorders, chronic fatigue syndrome, stiffness, anti-inflammatory effects in arthritis and certain central nervous system disorders that are impaired balance. |