| abstract |
The present invention relates to novel autotaxin inhibitory compounds and pharmaceutical compositions containing them for the treatment and prevention of conditions or diseases caused by activation of autotaxin or increased concentration of lysophosphatidic acid. The novel compound of the present invention is an autotaxin inhibitor which inhibits the production of lysophosphatidic acid and thus can be used for the treatment of cardiovascular diseases, cancer, metabolic diseases, kidney diseases, liver diseases, inflammatory diseases, neurological diseases, respiratory diseases, , Cholestatic form and other forms of chronic pruritus or acute or chronic organ transplant rejection. |