http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101794932-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-42 |
| filingDate | 2012-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101794932-B1 |
| titleOfInvention | Method for the preparation of a heat stable oxygen carrier-containing composition facilitating beta-beta cross-linking |
| abstract | There is provided a method for preparing a pharmaceutical composition containing a thermostable hemoglobin-based oxygen carrier favored by beta-beta crosslinking. The results of the present invention can be used to control the oxygen affinity of the resulting molecule and thus produce a hemoglobin-based oxygen carrier tailored to the particular application. Cross-linked hemoglobin with low oxygen affinity is useful for applications requiring rapid tissue oxygen supply (e.g., hemorrhagic shock), while cross-linked hemoglobin with high oxygen affinity requires low-rate oxygen supply Lt; / RTI > Highly purified and thermostable cross-linked non-polymeric cross-linked tetrameric hemoglobin is produced that has 40-60% or more of the beta-beta linkage and is suitable for use in mammals without causing renal damage. A high temperature short time (HTST) heat treatment step is performed to effectively remove undesirable dimeric forms of hemoglobin, noncrosslinked tetrameric hemoglobin, and plasma protein impurities. |
| priorityDate | 2011-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 497.