| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3f4111205626392f051303e7b8819 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2016-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43efae4519bb841b1005a8b1c0904228
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54e6647452eea53791369aeda2e3b9ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_153fa6f4c8fb62e84f2334ca3fd9859e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac00724de8e57b8bd9f054c73aae645a |
| publicationDate |
2017-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-101794313-B1 |
| titleOfInvention |
Composition comprisin Creb3L1/CrebA protein or polynucleotide encoding the CrebA/CREB3L1 for the prevention or treatment of neurodegenerative disease |
| abstract |
The present invention relates to a pharmaceutical composition for the prevention or treatment of a degenerative brain disease comprising CrebA / CREB3L1 protein or a polynucleotide encoding the same as an active ingredient. Specifically, the CrebA / CREB3L1 protein is an MJDtr-78Q protein of Machado-Joseph disease Restoration of GOP dysfunction and plasma membrane loss of toxic-induced dendrites, loss of C4da nerve cell dendrites, restoration of dendritic branch morphology, vesicle mediated transport, membrane structure, lipid Confirming that the synthesis is strongly related to CrebA, and confirming that the expression of CREB3L1 and Sec13 and Sec23A related to cell membrane transport in the human-derived HEK293T cell line is reduced by polyQ toxicity, the CrebA / CREB3L1 protein of the present invention and the The nucleotide is useful as a composition for preventing or treating degenerative brain diseases There. |
| priorityDate |
2016-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |