abstract |
Anticain antibodies bind to two, three, four, five or more CC chemokines such as RANTES / CCL5, MIP-1α / CCL3, MIP-1β / CCL4 or MCP-1 / CCL2. Methods of humanization and affinity maturation of anticain antibodies as well as generation of hybridoma cell lines that produce anticancer antibodies by sequential immunization are also disclosed. |