| abstract |
The present invention provides an anti-HCV compound having the general formula (I). A is O, S, CH, NH or NR ', when the bond O and Z₃, and Z₁ is N or CR Z1, Z₂ is CR Z2, and when the Z₁ and O bond, Z₂ is CH, Z₃ is C -Ar; R a, R b, R c and R d are independently H, OH, halogen or -Y 1 -R m ; A 1 is NH or CH 2 and R 1 'is hydrocarbon, aryl, hydrocarbonocyclohydrocarbyl, heterocycloalkyl or heteroaryl; A < 2 > is N, O or a bond; R 1 is hydrogen, or a C 5 -C 9 saturated or unsaturated O or N substituted hydrocarbon chain in which R 1 and R 3 are covalently bonded, and R 3 is a hydrocarbon, a cyclo-hydrocarbon, a heterocyclo-hydrocarbon, a hydrocarbon substituted with a cyclo-hydrocarbon, or the like; R < 4 > is alkoxy-CO, alkyl-NHCO, (alkyl) 2NCO or formyl substituted with aryl, cycloalkyl, heterocycloalkyl. |