| abstract |
The present invention relates to compounds of formula (I) (Wherein X 1 , X 2 , X 3 , X 4 , X 5 , R , R 1 and R 2 are as defined above). Such compounds are useful in the treatment of apoptosis signal-regulated kinase ("ASK1") inhibiting activity, and thus can be used for the treatment of autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic kidney diseases, mental disorders including kidney diseases, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis Lung injury, acute and chronic liver disease, and neurodegenerative diseases. The present invention also relates to pharmaceutical compositions comprising one or more compounds of formula (I), and to processes for the preparation of compounds of formula (I). |