| abstract |
The present invention relates to a pharmaceutical composition comprising a compound of the formula 1, 2 or 3, or a pharmaceutically acceptable salt thereof, a composition containing the compound, and a pharmaceutical composition comprising the compound in the treatment of various diseases, particularly diseases controlled or affected by androgen receptors It is about usage: [Chemical Formula 1] (2) (3) In this formula, A is N or -CR 0 -, wherein R 0 is hydrogen, C 1 -C 6 straight chain or branched chain alkyl and the like; Z is -CR e - or -N-, where R e is hydrogen, C 1 -C 6 straight or branched chain alkyl and the like; R 1 is hydrogen, C 1 -C 6 straight chain or branched chain alkyl and the like; R 2 is independently hydrogen, or C 1 -C 6 straight or branched chain alkyl; R 3 and R 4 are independently hydrogen, C 1 -C 6 straight chain or branched chain alkyl and the like; R 5 and R 6 are independently hydrogen, or C 1 -C 6 straight or branched alkyl; R 8 is hydrogen or the like, C 1 -C 6 straight or branched chain alkyl; R 9 and R 10 are independently hydrogen, or C 1 -C 6 straight or branched chain alkyl and the like; Q is -CO-, - (CH 2 ) q -, - (CHR s ) q - or - (CR s R t ) q - wherein R s and R t are independently C 1 -C 6 straight or branched Alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl and q is 0, 1, 2 or 3; n is 0, 1, 2, 3, 4 or 5; |