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filingDate 2017-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2017-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0a9f16ac5e168c8b658a207f48e6e56
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publicationDate 2017-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-101744900-B1
titleOfInvention Stable Liquid Composition Comprising Botulinum Toxin
abstract The present invention relates to a stable liquid composition comprising a ready-to-use botulinum toxin as an active ingredient without requiring a reconstitution process, and particularly relates to a stable liquid composition containing a botulinum toxin at a low concentration The present invention relates to a botulinum toxin which is capable of maintaining the activity of botulinum toxin per batch or liquid vial constantly, (I) a botulinum toxin as an active ingredient, (ii) L-alanine or methylcellulose, (iii) a nonionic surfactant and (iv) a buffering agent, optionally comprising an isotonic agent Lt; / RTI &gt; The liquid composition of the botulinum toxin according to the present invention can be used immediately without requiring a rehydration process so that the convenience of the user is improved and the deviation of botulinum toxin activity due to dilution errors during rehydration can be reduced . In addition, the liquid composition according to the present invention effectively prevents the coagulation of botulinum toxin even at a low botulinum toxin concentration, and is extremely excellent in storage stability, and the adsorption of botulinum toxin to a container is effectively prevented, There is an advantage that the activity of the botulinum toxin per vial can be maintained constant.
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018135722-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021235773-A1
priorityDate 2017-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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