| abstract |
The present invention relates to methods of treating cancer in humans and pharmaceutical combinations useful in such treatment. In particular, the process comprises reacting N- {3- [3-cyclopropyl-5- (2-fluoro-4-iodo-phenylamino) -6,8-dimethyl- Yl) phenyl} acetamide, or a pharmaceutically acceptable salt or solvate thereof, and N - {(1S) -tetrahydro-2H-pyrido [4,3-d] pyrimidin- (4-chloro-1-methyl-1H-pyrazol-5-yl) -2-thiophenecarboxylic acid ≪ / RTI > or a pharmaceutically acceptable salt thereof, to a human in need of such treatment. |