http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101736218-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4965 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-25 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4965 |
| filingDate | 2010-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101736218-B1 |
| titleOfInvention | Lysine Specific Demethylase-1 INHIBITORS THEIR USE |
| abstract | The present invention relates to compounds of formula I, or an enantiomer, diastereomer or mixture thereof, or a pharmaceutically acceptable salt or solvate thereof. (A) is heteroaryl or aryl which is covalently bonded to (B) and (A ') if (A) is present; (A ') is independently selected from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy and cyano, Wherein each (A ') has 0, 1, 2 or 3 substituents independently selected from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, amido and sulfinyl; X is 0, 1, 2 or 3; (B) is a cyclopropyl ring which is covalently bonded to (A) and (Z), wherein (A) and (Z) are covalently bonded to other carbon atoms of (B) and (Z) is -NH-; Thus, the (Z) nitrogen atom is covalently bonded to (B), (L) and a hydrogen atom; (L) is a linker covalently bonded to (Z) and (D), wherein said linker is selected from -CH 2 CH 2 -, -CH 2 CH 2 CH 2 -, and -CH 2 CH 2 CH 2 CH 2 - Selected; And (D) are selected from -N (-R1) -R2, -O-R3 and -S-R3, wherein: R1 and R2 together with the nitrogen atom to which R1 and R2 are attached form a heterocyclic ring order and connected to each other, wherein said heterocyclic ring is -NH 2, -NH (C 1 -C 6 alkyl), -N (C 1 -C 6 alkyl) (C 1 -C 6 alkyl), alkyl, halo 2, or 3 substituents independently selected from alkyl, alkoxy, haloalkyl, and haloalkoxy, or R 1 and R 2 are independently selected from -H, alkyl, cycloalkyl, haloalkyl, and heterocyclyl Wherein the sum of the substituents of R 1 and R 2 is 0, 1, 2 or 3 and the substituents are selected from the group consisting of -NH 2 , -NH (C 1 -C 6 alkyl), -N (C 1 -C 6 alkyl) (C 1 -C 6 alkyl), and is independently selected from fluorine; And R3 is -H, alkyl, cycloalkyl, haloalkyl, and is selected from heterocyclyl, wherein R3 is -NH 2, -NH (C 1 -C 6 alkyl), -N (C 1 -C 6 alkyl) ( C 1 -C 6 alkyl), and fluorine. The compounds of the invention initiate the inhibition of LSDl activity, which may be useful in the treatment or prevention of diseases such as cancer. (A) X- (A) - (B) - (Z) - (L) - (D) I |
| priorityDate | 2009-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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