http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101732707-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6267423dbf5278a615914354092dcc0e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2016-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e5ed2f6bd90cec94fb5c900f492105a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0def8b70ae3df5e8b07b97feac289c43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a127789fcf527f30e072223790d3d03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e55755b9d803b682453ca1f5c8a5794 |
| publicationDate | 2017-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101732707-B1 |
| titleOfInvention | Encephalomyelitis model mice, preparation method thereof, and screening method of therapeutic agent against encephalomyelitis using them |
| abstract | The present invention relates to an animal model of cerebrospinal fluid and a method for producing the same. The animal model of cerebrospinal fluid of the present invention is a mouse in which a Crif1 (CR6-interacting factor 1) gene is specifically deleted in a vascular endothelial cell, Induced mitochondrial dysfunction of vascular endothelial cells to reduce vascular endothelial dysfunction and tight junction between vascular endothelial cells, thereby causing collapse of vascular brain barrier, resulting in encephalomyelitis symptoms. In addition, there is provided a method for screening a therapeutic agent for encephalomyelitis using the encephalomyelitis animal model of the present invention. Accordingly, the encephalomyelitis animal model of the present invention is expected to be useful for studying the pathological mechanism of encephalomyelitis, and can be used for screening of a prophylactic and therapeutic agent for encephalomyelitis. |
| priorityDate | 2016-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.