| abstract |
The present invention relates to a pH-responsive metal-catechol derivative nanoparticle, particularly Fe (III) -dopa nanoparticle for drug delivery based on mussel adhesive protein, and a method for preparing the same. By using a catechol derivative-metal complex, especially a dopa-Fe (Ⅲ) complex, which is a pH-reactive substance based on a mussel adhesive protein, it is excellent in biocompatibility and can easily and quickly penetrate into target cells, Since the loaded drug is discharged, there is an effect that the drug can be selectively delivered to a specific disease having an acidic environment. |